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Hiromi Sesaki Selected Research

Dynamins (Dynamin)

8/2020Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.
1/2020Mitochondrial Fission Mediates Endothelial Inflammation.
1/2019Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
1/2017The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.
12/2016Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
11/2016Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
12/2014Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain.

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Hiromi Sesaki Research Topics

Disease

10Mitochondrial Diseases (Mitochondrial Disease)
06/2022 - 01/2012
7Neoplasms (Cancer)
12/2021 - 07/2014
4Bites and Stings (Sting)
06/2022 - 11/2017
4Alzheimer Disease (Alzheimer's Disease)
12/2016 - 01/2012
4Parkinson Disease (Parkinson's Disease)
01/2016 - 06/2011
3Obesity
11/2019 - 06/2013
3Inflammation (Inflammations)
01/2018 - 06/2013
2Carcinogenesis
08/2020 - 01/2018
2Insulin Resistance
11/2019 - 01/2017
2Hyperglycemia
11/2019 - 01/2018
2Weight Gain
01/2017 - 06/2013
2Infections
06/2016 - 06/2013
2Huntington Disease (Huntington's Disease)
06/2012 - 07/2011
1Liver Diseases (Liver Disease)
04/2022
1Diabetic Retinopathy (Retinopathy, Diabetic)
01/2021
1Hepatocellular Carcinoma (Hepatoma)
10/2020
1Heart Failure
10/2019
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2019
1Alcoholic Liver Diseases (Alcoholic Liver Disease)
01/2019
1Mental Disorders (Mental Disorder)
12/2018
1Mitochondrial Myopathies (Mitochondrial Myopathy)
11/2018
1Microcephaly
01/2018
1Nervous System Diseases (Neurological Disorders)
01/2018
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2018
1Ganglion Cysts (Ganglion)
10/2017
1Cardiovascular Diseases (Cardiovascular Disease)
07/2017
1Atherosclerosis
07/2017
1Hypoglycemia (Reactive Hypoglycemia)
01/2017
1Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy)
01/2017
1Brain Injuries (Brain Injury)
01/2017
1Muscular Atrophy (Muscle Atrophy)
01/2017
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2017
1Tauopathies
11/2016
1Premature Aging
04/2016
1Progeria (Hutchinson Gilford Syndrome)
04/2016
1Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
01/2016
1Frontotemporal Dementia With Motor Neuron Disease
01/2016
1Motor Neuron Disease (Primary Lateral Sclerosis)
12/2014
1Frontotemporal Dementia (Semantic Dementia)
08/2014
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
08/2014
1Reperfusion Injury
07/2014
1Brain Infarction
07/2014
1Nematode Infections
06/2013
1Autoimmune Diseases (Autoimmune Disease)
06/2013
1Body Weight (Weight, Body)
06/2013
1Weight Loss (Weight Reduction)
06/2013

Drug/Important Bio-Agent (IBA)

12Proteins (Proteins, Gene)FDA Link
12/2021 - 06/2011
7Dynamins (Dynamin)IBA
08/2020 - 12/2014
5Mitochondrial DNA (mtDNA)IBA
06/2022 - 08/2014
4Phosphoric Monoester Hydrolases (Phosphatases)IBA
12/2021 - 07/2014
3TensinsIBA
12/2021 - 07/2014
3Glucose (Dextrose)FDA LinkGeneric
01/2021 - 06/2013
3GTP Phosphohydrolases (GTPases)IBA
01/2020 - 01/2017
2LipidsIBA
12/2021 - 07/2014
2Carisoprodol (Soma)FDA LinkGeneric
01/2018 - 10/2017
2CollagenIBA
01/2018 - 07/2017
2Phosphatidylinositols (Phosphatidylinositol)IBA
01/2018 - 07/2014
2DNA (Deoxyribonucleic Acid)IBA
01/2018 - 11/2017
2EnzymesIBA
07/2014 - 06/2013
2Therapeutic UsesIBA
06/2013 - 06/2012
1RNA (Ribonucleic Acid)IBA
06/2022
1InterferonsIBA
06/2022
1Retinaldehyde (Retinal)IBA
01/2021
1CarcinogensIBA
10/2020
1Hypoglycemic Agents (Hypoglycemics)IBA
11/2019
1Metformin (Glucophage)FDA LinkGeneric
11/2019
1Adenosine Triphosphate (ATP)IBA
11/2019
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2019
1Antineoplastic Agents (Antineoplastics)IBA
10/2019
1HexokinaseIBA
01/2019
1Ethanol (Ethyl Alcohol)IBA
01/2019
1Lactic Acid (Lactate)FDA LinkGeneric
12/2018
1IonomycinIBA
01/2018
1CalciumIBA
01/2018
1GelsolinIBA
01/2018
1Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA
01/2018
1CaspasesIBA
01/2018
11,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl esterIBA
01/2018
1carbonyl 3-chlorophenylhydrazoneIBA
11/2017
1Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA
11/2017
1Matrix Metalloproteinases (MMPs)IBA
11/2017
1Alkaline PhosphataseIBA
07/2017
1Proprotein Convertase 9IBA
07/2017
1Collagen Type I (Type I Collagen)IBA
07/2017
1fibroblast growth factor 21IBA
01/2017
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
01/2017
1Pharmaceutical PreparationsIBA
01/2017
13- (2,4- dichloro- 5- methoxyphenyl)- 2- sulfanyl- 4(3H)- quinazolinoneIBA
01/2017
1Amyloid beta-PeptidesIBA
12/2016
1Methylene Blue (Methylthioninium Chloride)FDA Link
04/2016
1NucleotidesIBA
04/2016
1AntioxidantsIBA
04/2016
1Serine (L-Serine)FDA Link
02/2015
1Codon (Codons)IBA
12/2014
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
12/2014
1Dopamine (Intropin)FDA LinkGeneric
10/2014
1Peptides (Polypeptides)IBA
07/2014
1Hormones (Hormone)IBA
06/2013
1CytokinesIBA
06/2013

Therapy/Procedure

5Therapeutics
04/2022 - 01/2012